Inhibitory Properties of Aldehydes and Related Compounds against Phytophthora infestans-Identification of a New Lead.
Identifieur interne : 000148 ( Main/Exploration ); précédent : 000147; suivant : 000149Inhibitory Properties of Aldehydes and Related Compounds against Phytophthora infestans-Identification of a New Lead.
Auteurs : John J. Mackrill [Irlande (pays)] ; Roberta A. Kehoe [Irlande (pays)] ; Limian Zheng [Irlande (pays)] ; Mary L. Mckee [Irlande (pays)] ; Elaine C. O'Sullivan [Irlande (pays)] ; Barbara M Doyle Prestwich [Irlande (pays)] ; Florence O. Mccarthy [Irlande (pays)]Source :
- Pathogens (Basel, Switzerland) [ 2076-0817 ] ; 2020.
Abstract
The pathogen Phytophthora infestans is responsible for catastrophic crop damage on a global scale which totals billions of euros annually. The discovery of new inhibitors of this organism is of paramount agricultural importance and of critical relevance to food security. Current strategies for crop treatment are inadequate with the emergence of resistant strains and problematic toxicity. Natural products such as cinnamaldehyde have been reported to have fungicidal properties and are the seed for many new discovery research programmes. We report a probe of the cinnamaldehyde framework to investigate the aldehyde subunit and its role in a subset of aromatic aldehydes in order to identify new lead compounds to act against P. infestans. An ellipticine derivative which incorporates an aldehyde (9-formyl-6-methyl ellipticine, 34) has been identified with exceptional activity versus P. infestans with limited toxicity and potential for use as a fungicide.
DOI: 10.3390/pathogens9070542
PubMed: 32645837
PubMed Central: PMC7400633
Affiliations:
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Kehoe</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork</wicri:regionArea><wicri:noRegion>T12 K8AF Cork</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Limian" sort="Zheng, Limian" uniqKey="Zheng L" first="Limian" last="Zheng">Limian Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology, School of Medicine, University College Cork, T12 K8AF Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Physiology, School of Medicine, University College Cork, T12 K8AF Cork</wicri:regionArea><wicri:noRegion>T12 K8AF Cork</wicri:noRegion></affiliation></author><author><name sortKey="Mckee, Mary L" sort="Mckee, Mary L" uniqKey="Mckee M" first="Mary L" last="Mckee">Mary L. 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Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork</wicri:regionArea><wicri:noRegion>T12 K8AF Cork</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pathogens (Basel, Switzerland)</title><idno type="ISSN">2076-0817</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathogen <i>Phytophthora infestans</i> is responsible for catastrophic crop damage on a global scale which totals billions of euros annually. The discovery of new inhibitors of this organism is of paramount agricultural importance and of critical relevance to food security. Current strategies for crop treatment are inadequate with the emergence of resistant strains and problematic toxicity. Natural products such as cinnamaldehyde have been reported to have fungicidal properties and are the seed for many new discovery research programmes. We report a probe of the cinnamaldehyde framework to investigate the aldehyde subunit and its role in a subset of aromatic aldehydes in order to identify new lead compounds to act against <i>P. infestans</i>. An ellipticine derivative which incorporates an aldehyde (9-formyl-6-methyl ellipticine, <b>34</b>) has been identified with exceptional activity versus <i>P. infestans</i> with limited toxicity and potential for use as a fungicide.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32645837</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2076-0817</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>07</Day></PubDate></JournalIssue><Title>Pathogens (Basel, Switzerland)</Title><ISOAbbreviation>Pathogens</ISOAbbreviation></Journal><ArticleTitle>Inhibitory Properties of Aldehydes and Related Compounds against <i>Phytophthora infestans</i>-Identification of a New Lead.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E542</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/pathogens9070542</ELocationID><Abstract><AbstractText>The pathogen <i>Phytophthora infestans</i> is responsible for catastrophic crop damage on a global scale which totals billions of euros annually. The discovery of new inhibitors of this organism is of paramount agricultural importance and of critical relevance to food security. Current strategies for crop treatment are inadequate with the emergence of resistant strains and problematic toxicity. Natural products such as cinnamaldehyde have been reported to have fungicidal properties and are the seed for many new discovery research programmes. We report a probe of the cinnamaldehyde framework to investigate the aldehyde subunit and its role in a subset of aromatic aldehydes in order to identify new lead compounds to act against <i>P. infestans</i>. An ellipticine derivative which incorporates an aldehyde (9-formyl-6-methyl ellipticine, <b>34</b>) has been identified with exceptional activity versus <i>P. infestans</i> with limited toxicity and potential for use as a fungicide.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mackrill</LastName><ForeName>John J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Physiology, School of Medicine, University College Cork, T12 K8AF Cork, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kehoe</LastName><ForeName>Roberta A</ForeName><Initials>RA</Initials><Identifier Source="ORCID">0000-0003-2137-5429</Identifier><AffiliationInfo><Affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Limian</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Physiology, School of Medicine, University College Cork, T12 K8AF Cork, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McKee</LastName><ForeName>Mary L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Sullivan</LastName><ForeName>Elaine C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prestwich</LastName><ForeName>Barbara M Doyle</ForeName><Initials>BMD</Initials><AffiliationInfo><Affiliation>School of Biological, Earth and Environmental Sciences, University College Cork, T12 K8AF Cork, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Florence O</ForeName><Initials>FO</Initials><Identifier Source="ORCID">0000-0001-5837-1638</Identifier><AffiliationInfo><Affiliation>School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Western Road, T12 K8AF Cork, Ireland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>15S669</GrantID><Agency>Department of Agriculture, Food and the Marine, Ireland</Agency><Country></Country></Grant><Grant><GrantID>Elaine O'Sullivan & Mary McKee</GrantID><Agency>Irish Research Council for Science, Engineering and Technology</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Pathogens</MedlineTA><NlmUniqueID>101596317</NlmUniqueID><ISSNLinking>2076-0817</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Phytophthora infestans</Keyword><Keyword MajorTopicYN="N">cinnamaldehyde</Keyword><Keyword MajorTopicYN="N">ellipticine</Keyword><Keyword MajorTopicYN="N">fungicide</Keyword><Keyword MajorTopicYN="N">thiosemicarbazone</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate 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